Correlation between the Level of Creatinine, Serum Cardiac Troponines and Left Ventricle Function Tests in Patients with Chronic Renal Diseases without Acute Coronary Syndrome

Background and Objectives:  The aim of this study was to survey the relationship between the level of  creatinine,cardiac troponins serum and the function of  the left ventricle in patients with  kidney insufficiency,without acute coronary syndrome. Materialsand Methods:The sample  was150 patients with nondialysis chronic kidney disease without  acute  coronary  syndrome,  hospitalized  at  Imam  Khomeini  Center through  2008-2009.  All  the patients had serum creatinine (cr) 1.5mgor greater and no symptoms of acute coronary syndrome in the  first  month. Serum  Cr and troponin T and I  were  measured  in  blood samples and patients  left ventricular function (LVEF) were estimated by echocardiography. Then based on the objectives, the findings were analyzed with SPSS soft ware. Results:Serum troponin T levels were significantly higher in patients with greater Cr levels but there was no significant relationship between troponin I and Cr levels. Patients with greater degrees of LV dysfunction  had  significantly upper  levels of troponin T(P=0.0001). In this category, patients with diabetes, old age, cigarette smokers, greater levels of Cr, advanced stages of chronic kidney disease and greater degrees of LV dysfunction showedsignificantly higher levels of troponin T(P=0.0001). Conclusion:To identify chronic kidney disease patients at increased risk for cardiovascular events, serum troponin T can be used. In  high-riskpatients, the evaluation for cardiovascular diseases could be done earlier in the course of chronic kidney disease.